| THE BULLETIN OF TOKYO DENTAL COLLEGE | |
| Vol. 48 No. 4 November 2008 | |
| ISSN: 0040-8891 UBIC: 66 | |
Abstract |
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| In order to find informative salivary biomarkers specific to oral cancer we examined expression of
4 kinds of cytokine in saliva. Levels of interleukins (IL-1ß -6, -8) and osteopontin were measured by ELISA using whole
saliva samples collected from 19 patients with oral cancer (9 men, 10 women; mean age, 60.9 years) and 20 healthy persons
(15 men, 5 women; mean age, 32 years). Expression of the 4 cytokines was higher in patients with oral cancer than in healthy
controls. The difference was significant in IL-6, in particular. The results suggest that saliva offers a potential target
for a screening test aimed at detection of precancerous lesions.
Key words: Osteoma-Condyle-Acute pain-Limited-mouth-opening |
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