The Bulletín of Kanagawa Dental College.

Vol. 35 No. 2      September 2007

ISSN: 0385-1443      UBIC: 65

Abstract

Adult periodontitis is initiated by a primary pathogen such as Porphyromonas gingivalis. The presence of restraint stress showed a significant augmentatíon on P. gingivalis-challenged periodontitis in rats. We investigated the inhibitory effects of COX-2 inhibitor, alendronate and p-blocker on alveolar bone loss challenged by P. gingivalis and restraint stress in rats. In the groups treated with COX-2 inhibitor, alendronate and p-blocker, the increasing rate of body weight was decreased and the thymus and spleen were atrophied. The groups treated with COX-2 inhibitor, alendronate and p-blocker showed the remarkable inhibition in augmented alveolar bone loss challenged by P. gingivalis. It can be thought that COX-2 inhibitor is more effective in reducing alveolar bone loss because it seems to have less systemic influence and more inhibitory effect than the other drugs. Therefore, COX-2 inhibitor plays a crucial role in the pathogenesis of periodontitis, as systemic treatment prevented alveolar bone loss challenged by P. gingivalis. Key words: Alveolar bone loss, Porphyromonas gingivalis, CQX-2 inhibitor, Alendronate, ß -blocker.

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