| The Bulletín of Kanagawa Dental College | |
| Vol. 37 No. 1 MARCH- 2009 | |
| ISSN: 0385-1443 UBIC: 65 | |
| ABSTRACT | |
| Porphyromonas gingivalis, a gram-negative and black-pigmented anaerobe, has been etiologically associated with various types of periodontal
diseases including adult periodontitis. Moreover, host factors are important in the onset and progression of this disease. We recently developed a rodent model in
which alveolar bone loss was induced after oral infection of specific-pathogen-free rat with a human-derived strain of P. gingivalis in rats. In this review, we
used this rat model to determine the influence of the restraint stress and the sympathetic nervous system on periodontitis. The presence of restraint stress
significantly enhances the progression of P. gingivalis-challenged periodontitis in rats. And also, superior cervical ganglionectomy is an important accelerating factor
in alveolar bone loss. Thus, we suggest that the sympathetic nervous system is linked with the prevention of alveolar bone loss. These results present new information
on the occurrence of an increase in alveolar bone loss.
Key words: Stress / Periodontal disease / Immune responses / Sympathetic nervous system. |
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