| The Japanese Dental Science Review | |
| Vol. 44 No. 2 2008 | |
| ISSN: 1882-7616 UBIC: 99 | |
| SUMMARY | |
| Etiology of temporomandibular joint disorders (TMD) was estimated as excessive mechanical stresses inflicted on the temporomandibular joint
(TMJ). The stresses including bruxism, clenching and oral parafunctional habits in daily life cause irreversible damage in the joint tissue. As the stress loading
to the TMJ, it has been shown that increase of generation of free radicals, biosyntheses of arachidonic acid catabolite, release of neuropeptide and cytokines, and
activation of matrix degrading enzymes from various TMJ tissues were observed. Few studies of reactive oxygen species (ROS) in TMD were reported. The authors postulate
mechanisms that provably involved in the production of ROS in the TMJ and the subsequent induction of molecular events that may amplify damage to the joint tissues.
KEYWORDS: Reactive oxygen species; Oxidative stresses; Temporomandibular joint; Temporomandibular joint disorders. |
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