INTERNATIONAL JOURNAL OF ORAL-MEDICAL SCIENCES

Vol. 7 No. 1      September - 2008

ISSN: 1347-9733      UBIC: 136-M

Abstract

Relaxin (RLX) is a hormone in the insulin/RLX family of structurally related hormones. It has been shown to bind to receptors LGR7 and LGR8 in the leucine-rich repeat-containing G-protein-coupled receptor family. Furthermore, RLX influences many other physiologic processes such as collagen turnover, angiogenesis, and antifibrosis. Immunohistochemical studies have reported that RLX was localized in ovarian and other tissues. The present study focused on the localization of RLX in rat periodontal ligaments, midpalatal suture, and dental pulp tissue. To determine the localization of RLX proteins, an immunohistochemical study was performed. Positive immunoreactivity for RLX was identified in osteoblasts, osteoclasts, fibroblasts, collagen fibers, odontoblasts, and predentin in the periodontal ligaments, dental pulp, and midpalatal suture. Therefore, RLX may be involved in the process of collagen metabolism in the oral tissues. Keywords: relaxin, periodontal ligament, midpalatal suture, dental pulp.

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